Mathematical Studies of Transport and Exchange in Microcirculatory Physiology

微循环生理学中运输与交换的数学研究

基本信息

批准号：
8902472
负责人：
Eric Salathe
金额：
$ 14.45万
依托单位：
Lehigh University
依托单位国家：
美国
项目类别：
Continuing grant
财政年份：
1989
资助国家：
美国
起止时间：
1989-08-01 至 1993-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=8902472&HistoricalAwards=false
关键词：
Mathematical Studies Transport Exchange Microcirculatory

项目摘要

The objective of this research is to develop a mathematical theory to describe the exchange of substances across the walls of blood capillaries and the movement of these substances through the surrounding tissue. The purpose of the circulatory system is to transport oxygen and nutrients to every cell of the body and to remove carbon dioxide and waste products that the cells produce. Such substances cross the capillary wall by fairly well understood physical processes, and they move through the surrounding tissue either from the blood to the cells or from the cells to the blood by a variety of different transport mechanisms. In addition, there is a large movement of water across the capillary walls from the blood into the tissue or from the tissue into the blood; such fluid movement is critically related to fluid balance and swelling within the body. The objective of this proposal is to mathematically describe these complex processes in terms of the underlying basic physical principles. A predictive theory will be developed to indicate how the body functions under a broad range of normal and pathological conditions. Such a theory will provide deeper understanding of the underlying physiology. In addition, because it is predictive, it will provide information that supplements and extends experimental techniques, and will lead to a decreased need for relying exclusively on animal experimentation for physiological research.

这项研究的目的是开发一种数学理论来描述在血液毛细血管壁上的物质交换以及这些物质通过周围组织的运动。循环系统的目的是将氧气和养分运输到人体的每个细胞上，并去除细胞产生的二氧化碳和废物产物。这样的物质通过相当了解的物理过程穿越毛细管壁，它们通过周围的组织从血液到细胞或从细胞到血液移动到血液，通过各种不同的转运机制。另外，从血液到组织或组织进入血液的毛细管壁上有大量的水运动。这种流体运动与体内的流体平衡和体内肿胀密切相关。该提案的目的是数学上描述这些复杂的过程，从基本的基本物理原理来描述。将开发一种预测理论，以表明身体在广泛的正常和病理条件下如何发挥作用。这样的理论将提供对潜在生理学的更深入的理解。此外，由于它具有预测性，它将提供补充和扩展实验技术的信息，并将导致仅依靠动物实验进行生理研究的需求减少。