Biofabricated tissue mimics for nanoparticle design and development

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Nanoparticles are widely used in commercial applications spanning biotechnology, health and environmental monitoring, and drug delivery. Materials scientists can generate large libraries of nanoparticles, but the toolbox available to test these nanoparticles is limited. We will use biofabrication to comprehensively evaluate the fate of polymer grafted nanocellulose across simulated tissue barriers. Model blood vessels with recirculating flow will help understand permeation; tunable matrices will establish ‘matrix structure—nanoparticle diffusion’ criteria. The outcome from this project will be an understanding of how plastic nanoparticles penetrate tissue, to guide nanomaterials design and mitigate risk associated with toxicity.