Synthetic extracellular matrices for control of cellular reprogramming

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This project aims to design materials that control the cellular environment for the fast, efficient, and reproducible production of reprogrammed cells in embryo-like architectures. Regenerative medicine has entered a new era, where reprogramming a patient’s cells is now possible for studying and treating disease. The expected outcomes of this project include mechanistic details of cell reprogramming, design rules for 3D printing of living cells and commercially viable reprogramming materials. The project expects to contribute fundamental knowledge in materials and biomedical sciences, while providing tools that will benefit commercial ventures in cell and tissue manufacturing.