Synthetic extracellular matrices for control of cellular reprogramming

用于控制细胞重编程的合成细胞外基质

• 批准号: FT180100417
• 负责人: Prof Kristopher Kilian
• 金额: $ 60.99万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-10-18 至 2022-10-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100417
• 关键词: Synthetic; extracellular; matrices; control; cellular

This project aims to design materials that control the cellular environment for the fast, efficient, and reproducible production of reprogrammed cells in embryo-like architectures. Regenerative medicine has entered a new era, where reprogramming a patient’s cells is now possible for studying and treating disease. The expected outcomes of this project include mechanistic details of cell reprogramming, design rules for 3D printing of living cells and commercially viable reprogramming materials. The project expects to contribute fundamental knowledge in materials and biomedical sciences, while providing tools that will benefit commercial ventures in cell and tissue manufacturing.

该项目旨在设计控制细胞环境的材料，以快速，高效和可重复地生产胚胎样结构中的重编程细胞。再生医学已经进入了一个新时代，重新编程患者的细胞现在可以用于研究和治疗疾病。该项目的预期成果包括细胞重编程的机制细节，活细胞3D打印的设计规则和商业上可行的重编程材料。该项目预计将贡献材料和生物医学科学的基础知识，同时提供有利于细胞和组织制造商业企业的工具。