Characterization of Metabolism and Excretion Patterns of Pulpmill Effluent Components by Fish

鱼类对纸浆厂废水成分的代谢和排泄模式的表征

• 批准号: 8907738
• 负责人: Richard Strange
• 金额: $ 3.66万
• 依托单位: University of Tennessee Knoxville
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-15 至 1991-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8907738&HistoricalAwards=false
• 关键词: Characterization; Metabolism; Excretion; Patterns; Pulpmill

Long and Medium Term Research: Characterization of Metabolism and Excretion Patterns of Pulpmill Effluent Components by Fish. This award recommendation is made under the Program for Long and Medium-Term Research at Foreign Centers of Excellence. The program is designed to enable young U.S. scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research and the utilization of unique or complementary facilities, expertise and experimental conditions in foreign countries. The award will support a 12 month research visit by Dr. Marsha Black, University of Tennessee, with Dr. Aimo Oikari of the University of Joensuu, Finland. The researchers will use a tiered approach using both laboratory and field exposures to study the elimination of two pulpmill effluent components (dehydroabietic acid and 3,4,5- trichloroguiacol) and benzo?a!pyrene by fish via the gills, skin, kidney, and hepatobiliary system. Compound excretion patterns and rates of metabolite formation by trout will be quantified using an experimental chamber. Excretion of the model compounds will be characterized with and without preexposure to dilute pulpmill effluent or >-napthoflavone, a potent inducer of the monooxygenase enzyme system. Following these laboratory experiments under controlled conditions, whitefish will be caged in a lake receiving pulpmill effluents at locations 3-15 km from the effluent discharge area. Fish removed at specified intervals over the 6 month exposure period will be analyzed for metabolizing enzyme activities and metabolites of dehydroabietic acid and 3,4,5-trichloroguiacol. Results from laboratory and field studies will be used to evaluate the role of xenobiotic excretion in the adaptation of fish to chronic low-level pollution. The award recommendation provides funds to cover, as appropriate, international travel, local travel abroad, stipend, dependents' allowance, if applicable, and a flat administrative allowance of $250.00 for the U.S. home institution.

长期和中期研究：代谢和 鱼类对造纸废水成分的排泄规律。 该奖项是根据长期计划提出的， 在国外卓越中心的中期研究。 程序 旨在使年轻的美国科学家和工程师能够 在国外的研究机构进行长期研究， 证明卓越。 奖励为开展下列活动提供了机会： 联合研究和利用独特或互补的 国外的设施、专业知识和实验条件 国家 该奖项将支持玛莎·布莱克博士为期12个月的研究访问， 田纳西大学的Aimo Oikari博士 芬兰约恩苏。 研究人员将使用分层方法， 实验室和现场暴露，以研究消除两个 纸浆厂流出物组分（脱氢松香酸和3，4，5- 三氯愈创木酚）和苯并？一个！鱼通过鳃，皮肤， 肾脏和肝胆系统。 化合物排泄模式和 鳟鱼代谢物形成的速率将使用 实验室 模型化合物的排泄将 具有或不具有预先暴露于稀纸浆厂的特征 流出物或>-萘酮，单加氧酶的有效诱导剂 酶系统 在这些实验室实验之后， 在受控条件下，白鱼将被关在一个湖里， 纸浆厂废水，距离废水排放口3-15公里 区 在6个月内按规定时间间隔移走鱼类 将分析暴露期的代谢酶活性 以及脱氢枞酸和3，4，5-三氯愈创木酚的代谢物。 实验室和现场研究的结果将用于评估 外源性排泄在鱼类适应环境中的作用 长期低污染。 授标建议酌情提供资金， 国际旅行、出国当地旅行、津贴、家属津贴 津贴（如适用）和统一行政津贴， $250.00为美国家庭机构。