Age-associated increases in pro-inflammatory cytokines (e.g. TNF) contribute to impaired macrophage function and increased susceptibility to disease in the elderly.

与年龄相关的促炎细胞因子（例如 TNF）增加会导致巨噬细胞功能受损，并增加老年人对疾病的易感性。

• 批准号: 327778
• 负责人: Naidoo Aveshni
• 金额: $ 7.65万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-10-01 至 2017-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=327778&lang=en
• 关键词: Aging-Related Disease; Bone Marrow Transplants; Chronic Inflammation; Flow Cytometry; Infectious Disease; Inflammaging; Macrophage Impairment; Murine Chimeras; Susceptibility To Pneumonia; Tnf (Pro-Inflammatory Cytokines)

Aging is accompanied by increased levels of protein mediators, known as cytokines, and observable changes in immune cell function. This "inflammaging" is believed to contribute to numerous diseases associated with aging (e.g. cardiovascular disease, demen

衰老伴随着被称为细胞因子的蛋白质介体水平的增加，以及免疫细胞功能的明显变化。这种“炎症”被认为是导致许多与衰老有关的疾病(如心血管疾病、痴呆)的原因