Synthetic and Mechanistic Studies on Hypervalent Iodine Complexes ,

罗伯特·M.莫里亚蒂在 伊利诺伊大学化学系， 芝加哥将得到有机合成计划的支持。的 主要研究者将研究高价 碘化合物 这些新试剂用于 促进碳-碳键的形成将被强调， 探测烯丙基化、乙烯基化和烷基化反应， 底物包括嘧啶和嘌呤核苷。 对高价碘化学的兴趣是基于以下事实： I（III）试剂的反应模式类似于 Pb（IV）、Tl（III）和Hg（II）。 此外，由于该机制 涉及配体交换和还原性的I（III）反应 消除，相似之处存在于I（III）化学和 Pd、Pt和Ni的有机金属化学。

This research program of Dr. Robert M. Moriarty in the Department of Chemistry at the University of Illinois at Chicago will be supported by the Organic Synthesis Program. The principal investigator will study the reactions of hypervalent iodine compounds. The use of these novel reagents for promoting carbon-carbon bond formation will be stressed by probing allylation, vinylation and alkylation reactions on substrates including pyrimidine and purine nucleosides. Interest in hypervalent iodine chemistry is based on the fact that the reactivity pattern of I(III) reagents resembles that of Pb(IV), Tl(III) and Hg(II). Further, due to the mechanism of of I(III) reactions involving ligand exchange and reductive elimination, similarities exist between I(III) chemistry and the organometallic chemistry of Pd, Pt and Ni.