US-Switzerland Cooperative Research on the Effects of Insulin-like Growth Factor I From Dietary Colostrum

美国-瑞士合作研究膳食初乳中胰岛素样生长因子 I 的作用

• 批准号: 8913221
• 负责人: Craig Baumrucker
• 金额: $ 1.15万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-15 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8913221&HistoricalAwards=false
• 关键词: US; Switzerland; Cooperative; Research; Effects

This award provides partial support for a sabbatical research visit to Switzerland by Professor Craig R. Baumrucker of Pennsylvania State University. He will work with Professor Juergen Blum of the Institute of Animal Breeding of the University of Bern and Professors E. R. Froesch and J. Zapf of the Department of Internal Medicine, University of Zurich. They have mutual interest and complementary expertise in studies of the effects of bovine colostrum growth factor (IGF-I) in the neonatal calf. Dr. Blum has extensive experience in surgical and physiological work with ruminants; Dr. Baumrucker is more accomplished in the cellular-molecular aspects of the ruminant mammary gland. The specific objectives of their current research are to determine if dietary IGF-I in bovine colostrum affects intestinal growth in vivo and to quantify the survival of bioactive dietary IGF-I in the intestine of the calf. They will also investigate the occurrence of type I and II IGF receptors in intestinal membranes. The recent discoveries of numerous growth factors has opened a new and exciting era for the understanding of animal tissue development and growth, with implications for agricultural productivity as well as human biology. By testing the hypothesis that colostrum containing IGF-I has beneficial growth effects upon the bovine neonatal intestine, this study will contribute substantially to understanding of what happens to both colostrum and milk in the gut. Isolation of cell stimulatory factors and understanding of IGF-I are prerequisites for development of recombinant growth factors. Since human and bovine colostrum are identical, the results of this study may benefit the human species.

该奖项提供了部分支持的休假研究 克雷格R.鲍姆鲁克 宾夕法尼亚州立大学。 他将与教授 德国动物育种研究所的于尔根·布卢姆说， 伯尔尼大学和E. R. Froesch和J. Zapf 他是苏黎世大学内科学系的教授。 他们有共同的利益和互补的专业知识， 牛初乳生长因子作用的研究 （IGF-I）在新生小牛。 布鲁姆博士有广泛的 反刍动物外科和生理学工作经验; 鲍姆鲁克博士在细胞分子学方面 反刍动物乳腺的各个方面。 的具体目标 他们目前的研究是确定饮食中的IGF-I 影响体内肠道生长， 定量生物活性饮食IGF-I在 小牛的肠子 他们还将调查 I型和II型胰岛素样生长因子受体在肠 膜。 最近发现的众多生长因子开启了 了解动物组织的一个激动人心的新时代 发展和增长，对农业的影响 生产力以及人类生物学。 通过测试 含有IGF-I初乳有益于 生长对牛新生肠的影响，本研究 将大大有助于理解 发生在肠道中的初乳和牛奶中。 分离 细胞刺激因子和IGF-I的理解是 重组生长因子开发的先决条件。 由于人类和牛的初乳是相同的， 这项研究可能对人类有益。