US-Switzerland Cooperative Research: Protein Scaffold for Dual Differentiation

美国-瑞士合作研究：双重分化的蛋白质支架

• 批准号: 0436490
• 负责人: David Kaplan
• 金额: --
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0436490&HistoricalAwards=false
• 关键词: US; Switzerland; Cooperative; Research; Protein

0436490KaplanThis three-year US-Switzerland cooperative research project between David L. Kaplan of Tufts University and Lorenz Meinel of the Federal Institute of Technology (ETH) in Zurich, Switzerland, addresses studies of novel protein biomaterial matrices. The objective is to correlate the protein scaffold design structure in 3D silk biomaterials with drug delivery kinetics to control tissue specific outcomes.Intellectual MeritThe study will further understanding of a new family of protein based 3D silk biomaterials that have unique mechanical and biological properties. The investigators will functionalize silk biomaterials with drug delivery systems in in vitro adult human stem cells aimed at differentiation for bone and cartilage lineages. They will address drug delivery kinetics and associated mechanical properties of the matrices in order to accommodate the specific requirements of both the bone and cartilage tissues. This will be accomplished through optimization of the 3D silk scaffolds, control of their porosity and the mode of drug delivery.Broader ImpactsThe proposed research has potential for creating novel biomaterials for application to bone and cartilage tissue engineering and formation of bone and cartilage interfaces. Education is a key component. U.S. students will have an opportunity to interact in a multidisciplinary program that involves materials science and engineering, biology and chemistry. They will develop the skills needed to succeed in an international research environment. In addition the insights from the research will be included in courses and specialized lectures offered at Tufts University and ETH.

0436490卡普兰这项为期三年的美国和瑞士合作研究项目由大卫L。塔夫茨大学的卡普兰和瑞士苏黎世的联邦理工学院（ETH）的洛伦茨·迈内尔致力于新型蛋白质生物材料基质的研究。 目的是将蛋白质支架设计结构与药物输送动力学相关联，以控制组织特异性outcomes.Intellectual MeritThe研究将进一步了解一个新的蛋白质基3D丝生物材料家族，具有独特的机械和生物学特性。 研究人员将在体外成人干细胞中用药物输送系统使丝生物材料功能化， 骨和软骨谱系的分化。他们将解决药物输送动力学和相关的机械性能的矩阵，以适应骨和软骨组织的具体要求。 这将通过优化的三维丝支架，控制其孔隙率和药物deliver.Broader ImpactsThe模式的模式来实现，拟议的研究有可能创造新的生物材料应用于骨和软骨组织工程和骨和软骨界面的形成。 教育是一个关键组成部分。 美国学生将有机会在涉及材料科学与工程、生物学和化学的多学科课程中进行互动。 他们将培养在国际研究环境中取得成功所需的技能。 此外，该研究的见解将被纳入塔夫茨大学和ETH提供的课程和专业讲座中。