Single Electron Transfer. A Major Reaction Pathway in Organic Chemistry

在化学系有机动力学程序中的这个项目(单电子转移。有机化学中的主要反应途径)中，尤金·C·阿什比教授将研究单电子转移反应。这项工作的主旨是收集实验证据来支持单电子转移是有机化学中的主要途径这一命题。阿什比教授将用不同的卤代烷模型底物进行实验，试图辨别亲核脂肪族取代反应的电子转移性质。这些研究将涉及比率和立体化学作为离开群体的函数的比较。伯烷基卤化物与二异丙胺锂反应中的竞争自由基、碳负离子和卡宾中间体也在进行研究。Ashby教授还利用顺式烯酮异构化为反式烯酮的探针，在各种实验条件下研究了金属烷基与烯酮共轭加成的机理。

In this project ("Single Electron Transfer. A Major Reaction Pathway in Organic Chemistry") in the Organic Dynamics Program of the Chemistry Division, Professor Eugene C. Ashby will study single electron transfer reactions. The main thrust of the work is the gathering of experimental evidence to support the proposition that single electron transfer is a major pathway in organic chemistry. Professor Ashby will perform experiments with various alkyl halide model substrates in an attempt to discern the electron transfer nature of nucleophilic aliphatic substitution reactions. These studies will involve comparison of rate and stereochemistry as a function of leaving group. Competing radical, carbanion, and carbene intermediates in the reactions of primary alkyl halides with lithium diisopropylamide are also being investigated. Professor Ashby is also studying the mechanism of conjugate addition of metal alkyls to enones under a wide variety of experimental conditions using the probe of isomerization of the cis enone to the trans enone.