Construction and Evaluation of Self-Luminescent Biosensors

生物传感器将被建造和评估用于监测汞 和甲苯，并用于监测代谢 生物反应器中细胞的活性。 所有的生物传感器都是在 使用含有lux基因的微生物 响应于分析物的诱导而产生光。 光将 用一个简单的半导体二极管收集。的 微生物和光电二极管将被连接以产生 生物传感器设计 我们的方法的优点包括： 商业机会，适当的敏感性和选择性， 分析物、光收集的现有复杂性以及 分析，并概括的概念，以产生一个整体范围 能够报告其他环境毒物的类似装置， 药物、药品、生物体和许多其他生物化合物。

Biosensors will be constructed and evaluated for monitoring mercury and toluene in the environment and for monitoring the metabolic activity of cells in a bioreactor. The biosensors all operate on the same principle of using microorganisms containing the lux genes to produce light in response to induction by an analyte. The light will be collected with a simple semiconductor juction (diode). The microorganisms and the photodiode will be interfaced to produce a biosensor devise. Advantages of our approach include immediate commercial opportunities, appropriate sensitivity and selectivity for the analytes, existing sophistication of light collection and analysis, and generalizability of the concept to produce a whole range of similar devices capable of reporting other environmental toxicants, drugs, pharmaceuticals, organisms and many other biological compounds.