Biomechanical Foundation of Tissue Engineering of Arteries and Veins

该建议的目的是提高对血管壁应力和应变反应中血管生长和吸收的理解。工作包括a)将墙体的结构和力学参数与应力和应变联系起来的实验和理论工作，b)确定决定生长和再吸收的因素，以及c)确定应力和生长之间的关系。这项工作将为组织对机械干预的反应方式提供新的基础知识。该研究强烈依赖于先进的工程技术来描述组织特性，并应有助于“组织工程”领域的发展。

The goal of this proposal is to improve the understanding of the growth and resorption of blood vessels in response to stresses and strains in the vessel wall. The work includes a) experimental and theoretical work to relate structural and mechanical parameters of the wall to stresses and strains, b) determination of factors that determine growth and resorption, and c) determination of the relationship between stress and growth. The work will provide new fundamental knowledge about the way tissues respond to mechanical intervention. The research strongly depends on advanced engineering techniques to describe tissue characteristics, and should contribute to the developing field of "tissue engineering".