International Workshop on Molecular Approaches to Development in Dictyostelium, Turin, Italy, Sept. 9-15,1990

该奖项将用于支持将于1990年9月9日至9月15日在意大利都灵举行的关于利用分子方法促进变形虫生物盘基骨菌发育的国际讲习班。会议由加州大学圣地亚哥分校的William F. Loomis教授和都灵大学的Salvatore R. Bozzaro教授组织，将集中讨论三个主题：(1)影响基因表达的信号和信号转导机制；(2)转录和转录后调控机制；(3)特定蛋白的修饰及其与细胞功能的关系。先进技术在盘状盘基骨的不同分化方面的各种应用，在获得一组遗传上和生理上相同的细胞相互作用并分化成专门细胞类型的机制方面取得了丰硕的成果。适用于该系统的强大分子遗传技术的出现开辟了许多新的途径，这些途径不仅与盘基ostelium的发育有关，而且与所有多细胞生物，特别是胚胎发生过程中的相关过程有关。在盘基骨门复杂过程的理解方面取得的进展很大程度上得益于各实验室在国际会议上定期交流技术、结果和观点。在意大利举办这次会议确保了最活跃的意大利和西欧实验室的参与，并将促进新数据的快速传播和促进国际合作。

This award will support an international workshop on molecular approaches to development in the amoebal organism Dictyostelium to be held in Turin, Italy from September 9 to September 15, 1990. The meeting, organized by Prof. William F. Loomis of the University of California-San Diego and Prof. Salvatore R. Bozzaro of the University of Turin, will focus on three topics: (1) Signals and signal transduction mechanisms that affect gene expression; (2) Transcriptional and post-transcriptional control mechanisms; (3) Modifications of specific proteins and their relations to cellular functions. The various applications of advanced techniques to diverse aspects of the differentiations that occur in Dictyostelium discoideum have been fruitful in gaining a global understanding of the mechanisms by which a group of genetically and physiologically identical cells can interact and diverge into specialized cell types. The advent of powerful molecular genetic techniques applicable to this system has opened up many new avenues that are leading to insights relevant not only to Dictyostelium development but also to related processes that occur in all multicellular organisms, especially during embryogenesis. Advances in the understanding of complex processes in Dictyostelium have benefitted significantly from the periodic exchange of techniques, results and points of view between laboratories at international meetings. Hosting this meeting in Italy ensures the participation of the most active Italian and Western Europe laboratories and will facilitate the rapid dissemination of new data and foster international collabora- tions.