Eighth International Workshop on Molecular Aspects of Myeloid Stem Cell Developme

描述（由申请人提供）： 此会议补助金是为第八届两年一度的研讨会“骨髓干细胞发育和白血病的分子方面。“这是自1995年以来举行的第8次研讨会，定于2009年5月10日至13日在马里兰州安纳波利斯的洛伊斯安纳波利斯酒店举行。研讨会有约50名发言者，共有约100名与会者。白血病是一种造血干细胞的疾病，其经历分化阻滞和失控的扩增。该研讨会的重点是位于白血病易位断点的基因，如AML1，TEL，RARa和MLL，以及由于表观遗传改变或突变导致功能异常而异常表达的基因。这些因子的突变或异常水平与白血病发生有因果关系。小鼠基因靶向研究和患者样本的序列分析表明，这些相同的基因对正常造血至关重要。这些因子的功能在造血发育中是组合的，并且重叠网络内相互作用的复杂性使得单个研究者难以获得广泛的科学和临床视角来理解它们在正常造血和白血病发生中的作用。其目标是汇集在干细胞生物学，正常骨髓细胞和白血病的互补方面的专业知识的研究人员。来自美国、英国、欧洲和日本的基础和临床科学家聚集在一起讨论他们关于干细胞和造血调节因子的最新发现，例如转录因子，包括那些研究骨髓增生异常综合征和白血病机制和治疗的人，信号转导和通过基因突变或表观遗传修饰失调的细胞周期组分。目的是通过非正式介绍和讨论交流信息。年轻的研究人员（研究生，博士后研究员）约占参与者的50%，并有机会以海报或口头演讲的形式展示他们的工作。参与者对调节谱系特化和恶性造血的关键因素及其在白血病临床中的相关性有了更深入的了解。该研讨会独特地汇集了基础科学家，临床研究人员和初级研究人员，真正促进沟通和开放的思想交流，未发表的结果，交叉受精和合作研究的科学家之间的正常和白血病干细胞和骨髓发育，沿着转化白血病研究和白血病治疗。(End摘要）

DESCRIPTION (provided by applicant): This conference grant is for the 8th biennial workshop on "Molecular Aspects of Myeloid Stem Cell Development and Leukemia." This 8th workshop, in a series held since 1995, is scheduled for May 10-13, 2009 at the Loews Annapolis hotel in Annapolis, MD. The workshop hosts ~50 speakers, with a total of ~100 participants. Leukemia is a disease of hematopoietic stem cells that undergo a block in differentiation and a deregulated expansion. The workshop focuses on genes located at translocation breakpoints in leukemia such as AML1, TEL, RARa, and MLL, and on genes aberrantly expressed due to epigenetic alterations or function abnormally due to mutations. Mutations or abnormal levels of these factors are causally related to leukemogenesis. Murine gene-targeting studies and sequence analyses of patient samples show the critical importance of these same genes for normal hematopoiesis. The functions of these factors are combinatorial in hematopoietic development, and the complexity of interactions within overlapping networks makes it difficult for single investigators to gain wide scientific and clinical perspective to understand their roles in normal hematopoiesis and leukemogenesis. The goal is to bring together investigators with expertise in complementary aspects of stem cell biology, normal myelopoiesis and leukemia. Basic and clinician-scientists from the USA, England, Europe and Japan come together to discuss their latest findings on stem cells and hematopoietic regulators, e.g. transcription factors, including those who work on myelodysplastic syndrome and leukemia mechanisms and therapeutics, signal transducers and cell cycle components dysregulated through genetic mutations or epigenetic modifications. The aim is exchange of information through informal presentations and discussions. Young investigators (graduate students, postdoctoral fellows) comprise ~50% of participants and have the opportunity to present their work as posters or oral talks. Participants achieve greater understanding of the critical factors that regulate lineage specification and malignant hematopoiesis, and their relevance in the clinic in terms of leukemia. The workshop uniquely brings together basic scientist, clinician-investigators, and junior investigators in a manner that truly promotes communication and open exchange of ideas, unpublished results, cross-fertilization and collaborative research between scientists working on normal and leukemic stem cells and myeloid development, along with translational leukemia research and leukemia therapeutics. (End of Abstract)