Organic Chemistry: Effect of Solvents on Organic Reactivity and Selectivity - New Synthetic Methodology

有机合成计划正在资助 保罗·A博士的研究项目格里科 格里科医生会 继续他的研究的影响，溶剂对 发展新的控制模式的反应过程 反应性 这将导致生产敏感的新 生产我们所需的复杂物质的方法 农业和工业。 本研究的主要目的是：（1）进一步探讨 2-氮杂降冰片烯的杂环逆转，（2）开发一种 衍生自以下的N-氧化物的杂环逆转方法 N-取代的2-氮杂降冰片烯用于分子间和 分子内（3+2）环加成反应，和（3） 研究狄尔斯-阿尔德反应和克莱森重排， 3- 5 M高氯酸锂的乙醚溶液。 许多研究 预测将是一个基本性质，以确定 这些潜在有用新闻的范围和局限性 反应. 天然产物合成的应用将是 进行。

The Organic Synthesis Program is funding the continuation of the research program of Dr. Paul A. Grieco. Dr. Grieco will continue his studies of the influence of the solvent on the course of reactions to develop new modes of controlling reactivity. This will lead to the production of sensitive new methods for producing the complex substances needed by our agriculture and industry. The major thrust of this research is: (1) to probe further the heterocycloreversion of 2-azanorbornenes, (2) to develop a heterocycloreversion process for N-oxides derived from N-substituted 2-azanorbornenes for use in intermolecular and intramolecular (3+2) cycloaddition reactions, and (3) to examine Diels-Alder reactions and Claisen rearrangements in 3-5M lithium perchlorate in ether. Many of the studies projected will be of a fundamental nature in order to define the scope and limitations of these potentially useful new reactions. Applications to natural products synthesis will be conducted.