How does cannabis chemistry impact anti-inflammatory activity? Investigating the entourage effect hypothesis to inform product development and consumer choice

大麻化学成分如何影响抗炎活性？

• 批准号: 543338-2019
• 负责人: Harris, Cory
• 金额: $ 8.16万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699587
• 关键词: How; does; cannabis; chemistry; impact

Varying with plant genetics, growing conditions, harvest and post-harvest processing, the chemistry of cannabis is complex and leads to complex pharmacology. In addition to the predominant cannabinoids THC and CBD, cannabis contains a variety of other compounds with potential therapeutic effects. The complexity and diversity of cannabis chemistry present a challenge for industry in terms of quality assurance yet offer great opportunity for process optimization and the development of higher quality products. Canopy Health Innovations (CHI) is biopharmaceutical company focused on developing innovative cannabis-based products with the goal of developing a range of effective formulations and delivery mechanisms to serve patients in Canada and worldwide. CHI seeks to better understand how processing influences product chemistry and bioactivity in order to improve the understanding of cannabis-based medicines and products. The proposed research includes two complementary projects aiming to characterize the chemistry and pharmacology of different cannabis-derived extracts; the first focuses on operational impacts of extraction and processing while the second focuses on differences between cannabis strains. By tracking the fate of major cannabinoids, terpenes, and other molecules from plant material to commercial products, CHI will gain superior knowledge of cannabis as well as opportunities to optimize operations, develop new value-added products, and strengthen internal quality control. At the population level, Canadian patients and consumers will benefit from safer, more effective, and more consistent cannabis products as well as better evidence on which to base their decisions. At the industry level, our results will inform and elevate R&D activities across Canada, where the established cannabis industry can continue to build competitive advantage and secure its leadership on the global stage.

随着植物遗传、生长条件、收获和收获后加工的不同，大麻的化学成分复杂，导致复杂的药理作用。除了主要的大麻类化合物THC和CBD外，大麻还含有各种其他具有潜在治疗作用的化合物。大麻化学的复杂性和多样性对工业在质量保证方面提出了挑战，但也为优化工艺和开发更高质量的产品提供了极大的机会。 Canopy Health Innovation(CHI)是一家生物制药公司，专注于开发以大麻为基础的创新产品，目标是开发一系列有效的配方和给药机制，为加拿大和世界各地的患者服务。CHI试图更好地了解加工如何影响产品化学和生物活性，以提高对以大麻为基础的药物和产品的理解。 拟议的研究包括两个相辅相成的项目，旨在确定不同大麻提取物的化学和药理学特征；第一个项目侧重于提取和加工对业务的影响，第二个项目侧重于大麻品种之间的差异。通过追踪从植物原料到商业产品的主要大麻类、萜类和其他分子的命运，迟浩田将获得更好的大麻知识，以及优化运营、开发新的附加值产品和加强内部质量控制的机会。在人口层面，加拿大患者和消费者将受益于更安全、更有效和更一致的大麻产品以及更好的证据来做出决定。在行业层面，我们的结果将为加拿大各地的研发活动提供信息并提升其水平，在那里，老牌大麻行业可以继续建立竞争优势，并确保其在全球舞台上的领导地位。