A novel precision-engineered microfluidic chip for wear particle research

一种用于磨损颗粒研究的新型精密设计微流控芯片

• 批准号: DP240102971
• 负责人: Prof Joanne Tipper
• 金额: $ 38.57万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102971
• 关键词: novel; precision; engineered; microfluidic; chip

This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on healthy spinal disc cells. We expect our technological framework to become an invaluable tool for biomedical engineers, biologists, and bio-engineers to work together and generate clinically relevant in-vitro data that supports optimisation for spinal implant design, fabrication, and safety.

该项目旨在开发1-新的协议，以在体外从脊柱植入物中产生临床相关的磨损颗粒，以及2-用于制造具有定制的机械，材料和生物特性的新型微流体3D脊柱植入物芯片的技术框架。这将提供一种目前无法获得的具有成本效益的工具，可以调查磨损颗粒对健康椎间盘细胞的影响。我们希望我们的技术框架能够成为生物医学工程师、生物学家和生物工程师的宝贵工具，共同努力，生成临床相关的体外数据，支持脊柱植入物设计、制造和安全性的优化。