An Optical Microscope for Imaging Three-Dimensional Semitransparent Structures

用于三维半透明结构成像的光学显微镜

• 批准号: 8960413
• 负责人: Alon Schatzberg
• 金额: $ 4.87万
• 依托单位: A J Devaney Associates, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 1990-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8960413&HistoricalAwards=false
• 关键词: Optical; Microscope; Imaging; Three; Dimensional

This award provides funds to determine the feasibility of constructing an electro-optical microscope that has the capability of yielding high quality, quantitative images of three-dimensional semitransparent objects without the need of physically slicing the specimen prior to imaging. The microscope generates a reconstruction of the three-dimensional complex index of refraction of an object by digitally processing multiple Gabor holograms of the structure using the filtered back-propagation algorithm of diffraction tomography. The Phase I program has as its principal goal the determination of the practicality of the underlying microscopic principle in relation to the sensitivity of the reconstruction procedure to noise and other error sources and the determination of the imaging performance of such a microscope under less than ideal operating conditions. A prototype breadboard design of the system will be completed during the Phase I program.

该奖项提供资金，以确定的可行性， 建造一个电子光学显微镜 能够产生高质量的定量图像， 三维透明物体， 在成像之前物理切片样本。 显微镜 生成所述三维复合索引的重构 通过数字处理多个Gabor 使用过滤后的反向传播的结构的全息图 衍射层析成像算法 第一阶段计划， 其主要目标是确定的实用性， 与灵敏度相关的基本微观原理 噪声和其他误差源的重建过程 并且确定这样的成像性能 在不太理想的操作条件下使用显微镜。 一 将完成系统的原型试验板设计 在第一阶段计划中。