New Methods in Organometallic and Synthetic Organic Chemistry

有机金属和合成有机化学新方法

• 批准号: 9000353
• 负责人: Paul Helquist
• 金额: $ 23.5万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9000353&HistoricalAwards=false
• 关键词: New; Methods; Organometallic; Synthetic; Organic

The Synthetic Organic Program is funding Dr. Paul Helquist of the Department of Chemistry at the University of Notre Dame to continue his research on new methods in synthetic organic and organometallic chemistry. The important unifying themes among the subprojects are the construction of carbocyclic ring systems, the development of organometallic reagents with a special emphasis on transition metals, and the development of reactions that take place with asymmetric induction. First, iron-carbene complexes will be studied to test the ability of these reactive intermediates to undergo C-H insertion and cationic olefinic cyclization. Chiral-at-iron derivatives will be used to test aysmmetric versions of the reactions. Second, intermediates derived from the reaction between ketone enolates and cyclopropane derivatives will be used as precursors cyclopentanone annulation, formation of polycyclic fused cycloheptanone systems and three-carbon segments for the synthesis of large-ring systems. Third, the concept of diastereofacial selective coordination of alkenes and the subsequent use of the coordinated alkenes for chiral synthesis will be extended to include organic pi-donor ligands in general.

合成有机计划正在资助保罗·赫尔奎斯特博士， 圣母大学化学系 继续研究有机合成的新方法， 有机金属化学 其中重要的统一主题 子项目为碳环的构建 系统，开发有机金属试剂， 特别强调过渡金属， 不对称诱导发生的反应。 首先，将研究铁-卡宾络合物以测试铁-卡宾络合物的性质。 这些活性中间体经历C-H反应的能力 插入和阳离子烯烃环化。 铁手性 衍生物将用于测试非对称版本的 反应. 第二，反应产生的中间体 酮烯醇化物和环丙烷衍生物之间的关系将是 用作前体环戊酮成环，形成 多环稠合环庚酮体系和三碳 用于合成大环系统的片段。三是 烯烃的非对映选择性配位概念 以及随后将配位烯烃用于手性 合成将扩展到包括有机π-供体配体 梗概.