U.S.-Italy Symposium on Copper in Biological Systems, Manziana Italy, Sept. 23-29, 1990

这项美国-意大利奖将支持在意大利曼齐亚纳举行的跨学科会议，主题是生物系统中的铜。此次会议由耶希瓦大学爱因斯坦医学院的杰克·佩萨奇教授和罗马大学的布鲁诺·蒙多维教授共同主办，除美国和意大利外，还将有来自12个国家的15名代表参加。重点将是非蓝铜氧化酶，尽管专门讨论蓝铜、血青素、细胞色素氧化酶和铜在毒性和解毒机制中的作用的会议将包括在内。铜在生物系统中起着至关重要的作用。它是酶促反应、生物能过程和某些蛋白质结构完整性所必需的重要过渡金属。过量时，它可能是有毒的，既可以作为重金属中毒剂，也可以在反应中产生有毒的氧。考虑到生物铜系统的重要性，毫不奇怪，在美国、意大利和世界其他地区的许多实验室中，它们仍在进行积极的研究。尽管在各种科学会议上都讨论过这个主题，但Manzania会议因其多学科方法的广度和对铜研究的具体关注而与众不同。在这一领域采用的几项重要技术可以追溯到过去的曼扎尼亚会议的影响。除了作为多学科方法的交流中心之外，Manzania会议还为年轻的研究人员提供了一个培育的科学环境。自上次Manziana会议以来的五年里，该领域的方向发生了很大的变化，新的方法和对金属在生物学中的作用的理解使这个主题的会议成为可能。

This U.S.-Italy award will support an interdisciplinary meeting in Manziana, Italy on the topic of copper in biological systems. The meeting, organized by Professor Jack Peisach of the Albert Einstein College of Medicine of Yeshiva University and Professor Bruno Mondovi of the University of Rome "La Sapienza," will include 15 participants from twelve countries besides the U.S. and Italy. The emphasis will be on non-blue copper oxidases, although sessions devoted to blue copper, hemocyanin, cytochrome oxidase, and the role of copper in toxicity and detoxification mechanisms will be included. Copper plays a vital role in biological systems. It is an essential transition metal required for enzymatic reactions, bioenergetic processes, and for structural integrity of some proteins. In excess, it can be toxic, both through its role as a heavy metal intoxicant, but also in reactions that generate toxic oxygen species. Considering the importance of biological copper systems, it is not surprising that they remain under vigorous investigation in numerous laboratories throughout the United States, Italy, and other parts of the world. Although the topic has been discussed at various scientific meetings, the Manzania meetings have been exceptional for the breadth of their multidisciplinary approach and their specific focus on copper research. The introduction of several important techniques in the field can be traced back to the impact of past Manzania meetings. In addition to acting as a clearing house for a multidisciplinary approach, the Manzania meetings have provided a nurturing scientific environment for young investigators. In the five years since the last Manziana meeting, the direction of the field has changed considerably and new approaches and understanding of the role of metals in biology make the case for a meeting on this topic.