Long & Medium Term Research: X-ray Crystallography Studies of Phycobiliproteins

长的

• 批准号: 9007063
• 负责人: Michael Becker
• 金额: $ 2.63万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9007063&HistoricalAwards=false
• 关键词: Long; & Medium; Term; Research

Long & Medium-Term Research: X-Ray Crystallography Studies of Phycobiliproteins. This award recommendation is made under the Program for Long & Medium-Term Research at Foreign Centers of Excellence. The program seeks to enable U.S. scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research, and the use of unique or compli- mentary facilities, expertise and experimental conditions in foreign countries. This award will support a twelve-month visit by Dr. Michael Becker of the University of Washington to work with Prof. Dr. Robert Huber of the Max-Planck-Institut f>r Biochemie in Martinsried bei M>nchen, Germany, on "X-Ray Crystallography Studies of Phycobiliproteins." Phycobiliproteins of the cryptomonad algae have highly unusual spectral and morpho- logical characteristics. The principal investigator proposes to determine the structure of one of these proteins by X-Ray diffraction techniques. In order to find a phycobiliprotein suitable for X-Ray diffraction studies, the investigators will first isolate, partially characterize, and attempt to crystallize phycobiliproteins from several different species of the cryptomonad algae. Structural studies on these proteins could yield exciting information in at least two different areas of biochemistry: photosynthetic energy transfer, and protein folding and aggregation.

长期和中期研究：藻胆蛋白的X射线结晶学研究。该奖项的推荐是根据外国英才中心的长期和中期研究计划提出的。该计划旨在使美国科学家和工程师能够在国外被证明是优秀的研究机构进行长期研究。奖项提供了开展联合研究的机会，并利用外国独特或配套的设施、专门知识和实验条件。该奖项将支持华盛顿大学的Michael Becker博士为期12个月的访问，与德国Martinsry Be M&gt；nchen的Max-Planck-Institut f&gt；r BioChemie的Robert Huber教授合作进行“藻胆蛋白的X射线晶体研究”。隐单胞藻的藻胆蛋白具有极不寻常的光谱和形态特征。首席研究人员建议通过X射线衍射技术确定其中一种蛋白质的结构。为了找到一种适合于X射线衍射研究的藻胆蛋白，研究人员将首先从几种不同种类的隐单胞藻中分离、部分表征并尝试结晶藻胆蛋白。对这些蛋白质的结构研究至少可以在生物化学的两个不同领域产生令人兴奋的信息：光合作用能量转移，以及蛋白质折叠和聚集。