Pain and synovial pathotypes in AMP AIM

AMP AIM 中的疼痛和滑膜病理类型

基本信息

  • 批准号:
    10856445
  • 负责人:
  • 金额:
    $ 30.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-03-22 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

Clinical pain phenotypes and mechanisms in inflammatory arthri3s are poorly understood. The Accelera3ng Medicines Partnership Autoimmune and Immune-Mediated Disease (AMP-AIM) Program addresses common themes across autoimmune and inflammatory-mediated diseases, and understanding the complexity and impact of pain and the dissocia3on between pa3ent and physician perceived disease burden, not necessarily related to untreated inflamma3on, is a major unmet need. Pain phenotypes such as nocicep3ve (3ssue injury), nociplas3c (central sensi3za3on), and neuropathic pain and their contribu3on to therapeu3c non-response cons3tutes a cri3cal knowledge gap. Pain is a core domain affec3ng quality of life from the perspec3ve of pa3ents with Rheumatoid Arthri3s (RA), Psoria3c Spectrum Disorder (PSD), Sjögren’s disease, and Systemic Lupus Erythematosus (SLE). This supplement will support adding comprehensive and uniform measurements of pain phenotyping to exis3ng data collec3on in RA and PSD pa3ents with prominent synovial pathology and both peripheral and central pain sensi3za3on, in parallel with the harmonized efforts in SLE and SJD. Specifically, we will 1. Iden3fy pain phenotypes associated with peripheral and central mechanisms of pain and in treatment non-responders, using both pa3ent reported outcomes (PROMIS 29, 2016 Fibromyalgia Survey) and algometer measured Quan3ta3ve Sensory Tes3ng (QST) of joint-specific hyperalgesia with a trapezius reference to assess central pain sensi3za3on, 2. Iden3fy novel mediators of pain in the RA and PsA synovium building on work that iden3fied a gene signature correla3ng with pain, where axon sprou3ng and neuron projec3on organiza3on were among the most significantly enriched pathways. Using synovial biopsies obtained in AMP-AIM, we will apply 3-dimensional staining and volume imaging to understand the interac3ons between synovial sensory nerves and synovial cell types. These studies will provide novel insights into pain sensi3za3on, non-response, and new treatment approaches.
炎症性关节炎的临床疼痛表型和机制尚不清楚。的

项目成果

期刊论文数量(0)
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专利数量(0)

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Jennifer Howitt Anolik其他文献

Jennifer Howitt Anolik的其他文献

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{{ truncateString('Jennifer Howitt Anolik', 18)}}的其他基金

AIM-for-RA
RA 的 AIM
  • 批准号:
    10451387
  • 财政年份:
    2022
  • 资助金额:
    $ 30.73万
  • 项目类别:
AIM-for-RA
RA 的 AIM
  • 批准号:
    10595666
  • 财政年份:
    2022
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    8851812
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    9318123
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    8932656
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    10200988
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    10166379
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    9913036
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Cellular Dynamics at the Synovium-Bone interface in RA
RA 滑膜-骨界面的细胞动力学
  • 批准号:
    9276491
  • 财政年份:
    2014
  • 资助金额:
    $ 30.73万
  • 项目类别:
Human Transitional B Cells: Homeostasis, Function, and Impact of BCDT
人类移行 B 细胞:稳态、功能和 BCDT 的影响
  • 批准号:
    8528452
  • 财政年份:
    2013
  • 资助金额:
    $ 30.73万
  • 项目类别:

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