Biophysics of the brain’s waste disposal system: Understanding why we sleep

大脑废物处理系统的生物物理学：了解我们为什么睡觉

• 批准号: DP230101113
• 负责人: Dr Svetlana Postnova
• 金额: $ 27.31万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101113
• 关键词: Biophysics; brain; waste; disposal; system

This project aims to develop a new biophysical model of the brain, founded on the recently discovered glymphatic system responsible for waste disposal during sleep. It sets out to formulate, analyse, and validate rigorous new multiscale quantitative modelling – to advance the study of sleep and brain clearance dynamics, at timescales from hours to decades. Among expected outcomes are powerful models ready for application at both population and individual level, and testable predictions concerning the sleep patterns that lead to aggregation of waste in the brain and eventual cognitive decline. Project outcomes should also benefit society and the economy though translation into interventions for sleep disturbance – in future applied research.

该项目旨在开发一种新的大脑生物物理模型，该模型建立在最近发现的负责睡眠期间废物处理的胶质淋巴系统的基础上。它旨在制定，分析和验证严格的新多尺度定量建模-以推进睡眠和大脑清除动力学的研究，时间尺度从几小时到几十年。在预期的结果中，有一些强大的模型可以在人群和个人层面上应用，还有一些关于睡眠模式的可测试的预测，这些模式会导致大脑中的废物聚集，最终导致认知能力下降。在未来的应用研究中，项目成果还应通过转化为睡眠障碍的干预措施来造福社会和经济。