Studies on the Mechanism of Electrophilic Aromatic Substitution

芳香族亲电取代机理的研究

• 批准号: 9007784
• 负责人: Michael De Rosa
• 金额: $ 14万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-15 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9007784&HistoricalAwards=false
• 关键词: Studies; Mechanism; Electrophilic; Aromatic; Substitution

The Organic Dynamics Program will support Professor Michael De Rosa's investigation of the "Studies on the Mechanism of Electrophilic Aromatic Substitution" in the Chemistry Department at Pennsylvania State University, Delaware County. He and undergraduate research students will develop new methodology that will unambiguously demonstrate how many intermediates are present in electrophilic substitution reactions. The kinetics and products of the dichloroethanoic acid catalyzed chlorination of pyrroles with N-chlorobenzamides and the carboxylic acid catalyzed chlorination of methoxybenzenes with N-chloroacetanilides are being studied. The intramolecular selectivity and intramolecular selectivity will be determined in order to elucidate the role of pi complexes in the electrophilic substitution mechanism.

有机动力学计划将支持教授迈克尔德 Rosa对“关于生物学的机制的研究”的研究 化学中的“芳香亲电取代” 宾夕法尼亚州立大学，特拉华州县。 他和本科研究生将开发新的 这一方法将清楚地表明， 亲电取代反应中存在中间体 反应. 二氯乙酸的反应动力学及产物 吡咯与N-氯苯甲酰胺的催化氯化， 羧酸催化甲氧基苯氯化反应 正在研究N-氯乙酰苯胺。 的 分子内选择性和分子内选择性将 为了阐明π复合物在 亲电取代机制。