Studies on the Mechanism of Electrophilic Aromatic Substitution

有机动力学项目将支持迈克尔·德·罗萨教授在特拉华县宾夕法尼亚州立大学化学系开展的《芳香族亲电取代机理研究》的研究。他和本科生将开发新的方法论，明确证明亲电取代反应中存在多少中间体。研究了二氯乙酸催化的吡咯与N-氯苯甲酰胺的氯化反应和羧酸催化的甲氧基苯与N-氯乙酰苯胺的氯化反应的动力学和产物。为了阐明PI络合物在亲电取代机理中的作用，将测定分子内选择性和分子内选择性。

The Organic Dynamics Program will support Professor Michael De Rosa's investigation of the "Studies on the Mechanism of Electrophilic Aromatic Substitution" in the Chemistry Department at Pennsylvania State University, Delaware County. He and undergraduate research students will develop new methodology that will unambiguously demonstrate how many intermediates are present in electrophilic substitution reactions. The kinetics and products of the dichloroethanoic acid catalyzed chlorination of pyrroles with N-chlorobenzamides and the carboxylic acid catalyzed chlorination of methoxybenzenes with N-chloroacetanilides are being studied. The intramolecular selectivity and intramolecular selectivity will be determined in order to elucidate the role of pi complexes in the electrophilic substitution mechanism.