Long & Medium Term Research: Transport of Fluid and Macro- molecules in Polymeric Gels

长的

• 批准号: 9008275
• 负责人: Laurence Baxter
• 金额: $ 2.31万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9008275&HistoricalAwards=false
• 关键词: Long; & Medium; Term; Research

Long & Medium-Term Research: Transport of Fluid and Macro- molecules in Polymeric Gels. This award recommendation is made under the Program for Long & Medium-Term Research at Foreign Centers of Excellence. The program seeks to enable U.S. scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research, and the use of unique or comple- mentary facilities, expertise and experimental conditions in foreign countries. This award will support a twelve-month visit by Dr. Laurence T. Baxter to India to work with Dr. Ramesh A. Mashelkar, Director of the National Chemical Laboratory ıNCL! at Pune on "Transport of Fluid and Macromolecules in Polymeric Gels." Recently, the NCL has developed super-absorbent polymers, i.e., polymers capable of absorbing several hundred times their own weight of water or other liquids. NCL designed one such polymer, Jalshakti, to improve the ability of plants to obtain water in arid climates. NCL's polymers have potential uses in many areas, such as agriculture, medical and personal hygiene products, controlled-release drug delivery, and separations. The researchers plan to model the transport of fluid and macromolecules in polymer gels, incorporating hydrodynamic and steric effects, as well as the thermodynamic properties of the gel. They will use this model to predict macroscopic transport properties, such as diffusivity or hydraulic conductivity, as well as concentration and pressure profiles, from microscopic properties. Their goal is to relate structure to function, to take thermodynamic parameters and incorporate them into a framework to analyze dynamic transport effects. The will test the mathematical model experimentally, by measuring effective diffusivity, perme- ability, and macromolecular concentration profiles, through standard techniques available at NCL. The investigators hope that insight into transport within gels obtained from>a verifiable model will yield a rational basis for polymer design, and for optimization of system parameters for effective drug release or water absorption, or both. The award recommendation provides funds to cover, as appropriate, international travel, local travel abroad, stipend, dependents' allowance if applicable, and a flat administrative allowance of $250 for the U.S. home institution.

长期和中期研究：聚合物凝胶中流体和大分子的传输。 该奖项推荐是根据外国卓越中心长期和中期研究计划提出的。 该计划旨在使美国科学家和工程师能够在国外经过验证的卓越研究机构进行长期研究。 奖项为开展联合研究以及使用国外独特或互补的设施、专业知识和实验条件提供了机会。 该奖项将支持 Laurence T. Baxter 博士对印度进行为期 12 个月的访问，与国家化学实验室主任 Ramesh A. Mashelkar 博士合作！在浦那，主题为“聚合物凝胶中的流体和大分子的传输”。 最近，国家化学实验室开发出了超吸水性聚合物，即能够吸收自身重量数百倍的水或其他液体的聚合物。 NCL 设计了一种此类聚合物 Jalshakti，以提高植物在干旱气候下获取水分的能力。 NCL 的聚合物在许多领域具有潜在用途，例如农业、医疗和个人卫生产品、控释药物输送和分离。 研究人员计划模拟聚合物凝胶中流体和大分子的传输，结合流体动力学和空间效应以及凝胶的热力学性质。 他们将使用该模型从微观特性预测宏观传输特性，例如扩散率或水力传导率，以及浓度和压力分布。 他们的目标是将结构与功能联系起来，获取热力学参数并将其纳入框架中以分析动态传输效应。 他们将通过 NCL 提供的标准技术测量有效扩散率、渗透率和大分子浓度分布，对数学模型进行实验测试。 研究人员希望，从可验证的模型中获得的对凝胶内运输的深入了解将为聚合物设计以及优化系统参数以实现有效的药物释放或吸水或两者兼而有之提供合理的基础。 该奖项建议提供资金，酌情支付国际旅行、当地出国旅行、津贴、家属津贴（如果适用）以及美国本土机构 250 美元的统一管理津贴。