Conference on Calcium Entry and Action at the Presynaptic Nerve Terminal; Baltimore, Maryland; October 14-17, 1990

突触前神经末梢钙进入和作用会议；

• 批准号: 9009069
• 负责人: Martha Nowycky
• 金额: $ 1万
• 依托单位: New York Academy of Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-15 至 1991-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9009069&HistoricalAwards=false
• 关键词: Conference; Calcium; Entry; Action; Presynaptic

Calcium entry leads to the release of neurotransmitters in nerve terminals. Malfunctions in this fundamental process can result in neurological and neuromuscular diseases. Despite vigorous research, the actual mechanism whereby calcium entry regulates transmitter release is poorly understood. This conference will focus on nerve terminals; concentrating on the biophysical and pharmacological properties of nerve terminal calcium channels, the entry and distribution of calcium ions after the nerve impulse, the physiology of calcium-dependent transmitter release, and the mechanism by which calcium triggers secretory vesicle fusion. In addition, new experimental techniques will be highlighted. The conference will assemble some of the best investigators working in the area to discuss the current status of knowledge and to examine the most promising lines of future development.

钙离子进入导致神经末梢释放神经递质。这一基本过程中的故障可能导致神经和神经肌肉疾病。尽管进行了大量的研究，但钙离子进入调节递质释放的实际机制尚不清楚。本次会议将集中在神经末梢，集中在神经末梢钙通道的生物物理和药理学特性，神经冲动后钙离子的进入和分布，钙依赖递质释放的生理，以及钙触发分泌囊融合的机制。此外，还将重点介绍新的实验技术。会议将召集一些在该领域工作的最好的研究人员，讨论知识的现状，并审查最有希望的未来发展路线。