Regulation of Calcium-Secretion Coupling in Chromaffin Cells: Role of the Cytoskeleton

[9319693]神经元和内分泌细胞释放化学信使与其他细胞交流。释放的触发信号开始于钙从细胞外环境的进入。钙离子似乎以一种协调的方式作用于许多蛋白质，使释放过程发生。在这项拨款申请中，我们将使用单细胞释放的实时测量来研究细胞内钙进入的反应，这是释放所必需的

9319693 Nowycky Neurons and endocrine cells release chemical messengers to communicate with other cells. The triggering signals for release begin with the entry of calcium from the extracellular environment. Calcium ions appear to act on many proteins in a coordinated fashion for the release process to occur. In this grant proposal, we will use real- time measurements of release from single cells to study the intracellular responses to calcium entry which are necessary for release.***