Feasibility Study of a New Concept for Regulating the Bio- degradation of Absorbable Synthetic Polymers and Fibers

调节可吸收合成聚合物和纤维生物降解新概念的可行性研究

• 批准号: 9009422
• 负责人: C. C. Chu
• 金额: --
• 依托单位: Cornell Univ - State: AWDS MADE PRIOR MAY 2010
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9009422&HistoricalAwards=false
• 关键词: Feasibility; Study; New; Concept; Regulating

The goal of this exploratory research is to develop a method to control the degradation properties of implanted materials. The approach is to deposit negative charges on the implant material using low-temperature gas plasma technology. The negative surface charges are expected to repel the negative OH ions involved in hydrolytic degradation mechanisms. The work will test the hypothesis that the degradation rate of surface-treated synthetic absorbable polymers will be reduced when compared with those of untreated materials. The degradation rate will be determined using several quantitative techniques. If successful, this research will open up a new way of designing implant materials for specific degradation rates. Moreover, the possibility also exists that the degradation rate may be controllable externally.

本探索性研究的目标是开发一种方法来控制植入材料的降解性能。该方法是使用低温气体等离子体技术在植入材料上存款负电荷。预计负表面电荷会排斥参与水解降解机制的负OH离子。该工作将检验以下假设：与未处理材料相比，经表面处理的合成可吸收聚合物的降解速率将降低。将使用几种定量技术测定降解速率。如果成功，这项研究将开辟一种设计特定降解率植入材料的新方法。此外，还存在降解速率可以从外部控制的可能性。