Effects of Nerve Growth Factor on Nucleus Basalis Magnocellularis Cholinergic Cell Recovery and Function

这项研究将调查一种名为神经生长因子的大蛋白在经历了特定脑损伤的大鼠中促进功能恢复的能力。在对含有乙酰胆碱的脑神经元产生损伤后，神经生长因子将被注入大脑。它对大脑生化和由损伤产生的异常行为的影响将被检测。这项工作很重要，因为它将提供有关特定化学物质如何作用于促进脑损伤后功能恢复的信息。

This research will investigate the ability of a large protein, called nerve growth factor, to promote functional recovery in rats who have undergone specific brain lesions. After producing injury to acetylcholine-containing brain neurons, nerve growth factor will be administered into the brain. Its effects on both brain biochemistry and on abnormal behavior produced by the lesioning will be examined. This work is important because it will provide information about how specific chemicals may work to promote recovery of function after brain damage.