Effects of Nerve Growth Factor on Nucleus Basalis Magnocellularis Cholinergic Cell Recovery and Function

神经生长因子对大细胞基底核胆碱能细胞恢复和功能的影响

• 批准号: 9010252
• 负责人: Leon Thal
• 金额: $ 27万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9010252&HistoricalAwards=false
• 关键词: Effects; Nerve; Growth; Factor; Nucleus

This research will investigate the ability of a large protein, called nerve growth factor, to promote functional recovery in rats who have undergone specific brain lesions. After producing injury to acetylcholine-containing brain neurons, nerve growth factor will be administered into the brain. Its effects on both brain biochemistry and on abnormal behavior produced by the lesioning will be examined. This work is important because it will provide information about how specific chemicals may work to promote recovery of function after brain damage.

这项研究将调查一个大的 蛋白质，称为神经生长因子，以促进功能 在经历了特定脑损伤的大鼠中恢复。 在对含乙酰胆碱的脑神经元产生损伤后， 将神经生长因子注入大脑 其 对大脑生化和异常行为的影响 将检查由损伤产生的。 这项工作是 重要的是，它将提供有关如何具体 化学物质可以促进脑功能的恢复 损害