The role of a conserved inter-domain linker in the activation of CTP: phosphocholine cytidylyltransferase

保守的域间连接子在 CTP 激活中的作用：磷酸胆碱胞苷酰转移酶

• 批准号: 367190
• 负责人: Knowles Daniel G
• 金额: $ 1.27万
• 依托单位: Simon Fraser University (Burnaby, B.C.)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-12-01 至 2017-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367190&lang=en
• 关键词: Activation Mechanisms; Allostery; Biomembranes; Enzyme Regulation; Genetic Disease; Inter-Domain Signaling; Lipid Metabolism; Membrane Homeostasis; Protein-Lipid Interactions; Structural Biology

Disease-associated mutations in enzymes often result in dysregulation of vital cell functions, leading to detrimental effects on organisms. Understanding how an enzyme's activity is regulated on a molecular level is important for understanding how these m

与疾病相关的酶突变常常导致重要细胞功能失调，对生物体造成有害影响。了解酶的活性是如何在分子水平上被调节的，对于理解这些细胞是如何形成的非常重要