Flow Studies in a Collapsible Tube With Sequential Constrictions

这一提议的动机是希望更好地了解冠状动脉中含有多个阻塞的血流。其前提是在脉动流动条件下，上游阻塞的顺应性和两个阻塞之间的距离强烈影响动脉内的压流量关系。对流环的实验观察将与理论推导的预测进行比较。该项目可能会对冠状动脉多发性阻塞的发展产生新的认识，也可能导致冠状动脉造影更深刻的解释。

This proposal is motivated by the desire to better understand blood flow in coronary arteries that contain more than one obstruction. It is based on the premise that under pulsatile flow conditions the compliance of the upstream obstruction and the distance between the two obstructions strongly affect the pressure vs flow relationship in the artery. Experimental observations on a flow-loop will be compared with predictions derived theoretically. The project may yield new understanding of the development of multiple obstructions in coronary arteries, and may also lead to more incisive interpretations of coronary angiograms.