Biochemical Genetics of Host-selective Toxin Biosynthesis

宿主选择性毒素生物合成的生化遗传学

• 批准号: 9016949
• 负责人: Jonathan Walton
• 金额: $ 21万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-15 至 1995-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9016949&HistoricalAwards=false
• 关键词: Biochemical; Genetics; Host; selective; Toxin

A plant pathogenic fungus in the economically-important genus Cochliobolus is the object of a study designed to examine the genetics of production of a cyclic-peptide, host-selective toxin produced by the fungus. To be examined is whether a 22kb stretch of DNA is a gene cluster encoding all of the enzymes involved in synthesis of the toxin; insights into the evolution of host- selective toxin production in this fungal genus should result from these studies, as well. The production of a host-selective toxin by a plant pathogenic, economically important fungus is to be studied by techniques suitable for determining whether a particular region of DNA encodes the several enzymes involved in synthesis of the cyclic-peptide toxin.//

一种具有重要经济意义的植物病原真菌是一项研究的对象，旨在研究由真菌产生的环状肽和宿主选择性毒素的遗传学。有待检验的是，一段22kb的DNA片段是否是编码毒素合成过程中所有酶的基因簇；深入了解宿主选择性毒素生产在这种真菌属的进化应该从这些研究中得出。一种具有重要经济意义的植物致病性真菌对宿主选择性毒素的产生，需要用合适的技术来研究，以确定DNA的某个特定区域是否编码参与合成环肽毒素的几种酶。//