Oxygen and Sulfide Delivery to Intracellular Bacterial Symbionts
氧气和硫化物输送至细胞内细菌共生体
基本信息
- 批准号:9017722
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing grant
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-02-01 至 1994-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cytoplasmic hemoglobins characteristic of nearly all bivalves and gastropod molluscs in which chemoautotrophic bacteria are present as internal symbionts appear vital to the symbiosis. Three such hemoglobins, from gills of the clam Lucina, have been isolated and their interactions with either sulfide or oxygen determined. The role(s) of these hemoglobins in the symbiotic association will now be examined using broken-cell systems containing symbiotic bacteria, kpurified gill hemoglobins, sulfide, and oxygen. The molecular mechanisms of cytoplasmic hemoglobin-mediated oxygen delivery and sulfide delivery to the bacterial symbionts will be studied; the effects of reduction of either heme or the ligand on ligand dissociation will be examined. Our understanding of the means whereby the bacteria utilize carbon dioxide using energy gained from sulfide oxidation, thus supporting life of this clam and other similar macrobes should be enhanced by these studies. The particular roles and mechanisms whereby hemoglobins, present in the cytoplasm of certain marine invertebrates in which an unusual symbiosis involving internalized chemoautotrophic bacteria exists, will be studied in terms of the ability of the invertebrate's hemoglobins to transport oxygen and sulfide to the bacteria. This inter-dependence of micro- and the macro-organism is an increasingly recognized one; an understanding of the means whereby sulfide, toxic to the invertebrate, reaches the symbiont and is protected from oxygen should be enlarged by this study. //
几乎所有双壳类和腹足类软体动物的细胞质血红蛋白,其中化学自养细菌作为内部共生体存在,似乎对共生至关重要。已经从文蛤的鳃中分离出三种这样的血红蛋白,并确定了它们与硫化物或氧气的相互作用。现在将使用含有共生菌、提纯的鳃血红蛋白、硫化物和氧气的破碎细胞系统来研究这些血红蛋白在共生关系中的作用(S)。将研究胞质血红蛋白介导的氧传递和硫化物传递到细菌共生体的分子机制;将检测血红素或配体的还原对配体解离的影响。通过这些研究,我们对细菌如何利用从硫化物氧化中获得的能量来利用二氧化碳,从而维持文蛤和其他类似微生物的生命的方法的理解应该会得到加强。存在于某些海洋无脊椎动物细胞质中的血红蛋白的特殊作用和机制将从无脊椎动物的血红蛋白向细菌输送氧气和硫化物的能力方面进行研究。在这些海洋无脊椎动物细胞质中,存在着涉及内化自养细菌的不寻常的共生。这种微观和宏观有机体之间的相互依赖关系日益得到认可;这项研究应该扩大对对无脊椎动物有毒的硫化物到达共生体并保护其免受氧气影响的方式的理解。//
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jonathan Wittenberg其他文献
Protecting global sexual and reproductive health and rights in the face of retrograde US policies and positions
面对美国的倒退政策和立场,维护全球性与生殖健康及权利
- DOI:
10.1016/s0140-6736(25)00618-x - 发表时间:
2025-05-10 - 期刊:
- 影响因子:88.500
- 作者:
Susheela Singh;Gilda Sedgh;Elizabeth A Sully;Onikepe Owolabi;Jonathan Wittenberg - 通讯作者:
Jonathan Wittenberg
Jonathan Wittenberg的其他文献
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{{ truncateString('Jonathan Wittenberg', 18)}}的其他基金
Hemoglobins in Mollusc/Bacteria Symbioses
软体动物/细菌共生中的血红蛋白
- 批准号:
8703328 - 财政年份:1987
- 资助金额:
-- - 项目类别:
Standard Grant
Cytoplasmic Oxygen Transport in Rhizobial Symbioses
根瘤菌共生中的细胞质氧运输
- 批准号:
8416001 - 财政年份:1985
- 资助金额:
-- - 项目类别:
Continuing grant
Reactions of Plant Hemoglobins with Ligands
植物血红蛋白与配体的反应
- 批准号:
8416016 - 财政年份:1985
- 资助金额:
-- - 项目类别:
Standard Grant
Role of Leghemoglobin and a Closely Associated Iron Protein In Nitrogen Fixation
豆血红蛋白和密切相关的铁蛋白在固氮中的作用
- 批准号:
8303698 - 财政年份:1983
- 资助金额:
-- - 项目类别:
Standard Grant
Molecular Interactions of Leghemoglobin, Cytoplasmic Proteins and Bacteroid Terminal Oxidases in Nitrogen Fixation
豆血红蛋白、细胞质蛋白和类杆菌末端氧化酶在固氮过程中的分子相互作用
- 批准号:
8004472 - 财政年份:1980
- 资助金额:
-- - 项目类别:
Continuing grant
Interactions of Leghemoglobin, Cytoplasmic Proteins and Bacteroid Terminal Oxidases in Nitrogen Fixation
豆血红蛋白、细胞质蛋白和类杆菌末端氧化酶在固氮中的相互作用
- 批准号:
7806073 - 财政年份:1978
- 资助金额:
-- - 项目类别:
Continuing grant
Interactions of Leghemoglobin, Cytoplasmic Proteins and Bacteroid Terminal Oxidases in Nitrogen Fixation
豆血红蛋白、细胞质蛋白和类杆菌末端氧化酶在固氮中的相互作用
- 批准号:
7607572 - 财政年份:1976
- 资助金额:
-- - 项目类别:
Continuing grant
Oxygen Secretion in the Teleost Swimbladder
硬骨鱼鳔的氧气分泌
- 批准号:
7405157 - 财政年份:1974
- 资助金额:
-- - 项目类别:
Standard Grant
Linked Functions and Intermolecular Interactions of a Monomeric Hemoglobin
单体血红蛋白的关联功能和分子间相互作用
- 批准号:
7202491 - 财政年份:1973
- 资助金额:
-- - 项目类别:
Continuing grant
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