How do apicomplexan parasites steal amino acids from their hosts?

顶复门寄生虫如何从宿主那里窃取氨基酸？

• 批准号: DP230100853
• 负责人: A/Prof Giel van Dooren
• 金额: $ 60.8万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100853
• 关键词: How; do; apicomplexan; parasites; steal

The single-celled parasites that cause malaria and toxoplasmosis are adept at stealing nutrients from the host animals that they infect. How they do this is, however, poorly understood. This project seeks to identify the processes by which these parasites scavenge amino acids, an essential class of nutrient, from their hosts. Using innovative experimental approaches, the project aims to identify and characterise the parasite proteins that mediate the uptake of different amino acids into the parasite. The intended outcomes of the project are to provide comprehensive insights into a fundamental aspect of parasite biology, and inform strategies to treat the diseases caused by these parasites by cutting off their nutrient supply.

引起疟疾和弓形虫病的单细胞寄生虫善于从它们感染的宿主动物那里窃取营养。然而，人们对它们是如何做到这一点的却知之甚少。该项目旨在确定这些寄生虫从其宿主体内吸收氨基酸（一种必需的营养物质）的过程。利用创新的实验方法，该项目旨在识别和鉴定介导寄生虫吸收不同氨基酸的寄生虫蛋白质。该项目的预期成果是为寄生虫生物学的一个基本方面提供全面的见解，并为通过切断其营养供应来治疗这些寄生虫引起的疾病的战略提供信息。