Purchase of a Circular Dichrograph and UV-VIS-NIR Spectrophotometer

购买圆二色仪和紫外-可见-近红外分光光度计

• 批准号: 9021680
• 负责人: Kevin Peters
• 金额: $ 4.32万
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-15 至 1992-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9021680&HistoricalAwards=false
• 关键词: Purchase; Circular; Dichrograph; UV; VIS

Measurements of optical activity have long played an essential role in the development of organic chemistry and biochemistry. The study of optical rotatory dispersion (ORD) or circular dichroism (CD) provides important information about the electronic states or structures of individual molecules or ions. These techniques are used when studying absolute configurations of molecules, reaction mechanisms and kinetics, asymmetric or stereospecific syntheses, thermodynamic properties of dissolved species, and many other stereochemical problems. This award from the Chemistry Research Instrumentation Program to the Department of Chemistry at the University of Colorado at Boulder will help them acquire a Circular Dichrograph. The acquisition will enhance chemical research in the following areas: 1. Circular Dichroism as a Method for Probing Ribozyme Conformation and Substrate Binding. 2. Applications of Circular Dichroism in Studies of Protein Structural Dynamics. 3. Solution Structures of Antimicrobial Peptides. 4. Analysis of Protein Circular Dichroism by Theory and Experiment. 5. Magnetic Circular Dichroism.

长期以来，光学活性的测量一直是 在有机化学和生物化学发展中的作用。 旋光色散（ORD）或圆偏振的研究 二向色性（CD）提供了关于 单个分子的电子状态或结构， 离子。 这些技术用于研究绝对 分子构型，反应机理和动力学， 不对称或立体定向合成，热力学 溶解物质的性质，以及许多其他立体化学 问题 化学研究仪器计划的这个奖项 到科罗拉多大学化学系， 博尔德将帮助他们获得圆二色谱仪。 的 收购将加强化学研究在以下方面 区域： 1. 圆二色谱法用于检测核酶 构象和底物结合。 2. 圆二色性在蛋白质研究中的应用 结构动力学 3. 抗菌肽的溶液结构。 4. 蛋白质圆二色性的理论分析和 实验 5. 磁性圆二色性