Purchase of a Circular Dichrograph and UV-VIS-NIR Spectrophotometer

旋光性的测量长期以来在有机化学和生物化学的发展中扮演着重要的角色。旋光色散(ORD)或圆二色谱(CD)的研究提供了有关单个分子或离子的电子态或结构的重要信息。这些技术用于研究分子的绝对构型、反应机理和动力学、不对称或立体定向合成、溶解物种的热力学性质以及许多其他立体化学问题。这项由化学研究仪器计划授予科罗拉多大学博尔德分校化学系的奖项将帮助他们获得圆形二色记录仪。此次收购将加强以下领域的化学研究：1.圆二色谱作为检测核酶构象和底物结合的方法。2.圆二色谱在蛋白质结构动力学研究中的应用3.抗菌肽的溶液结构。4.蛋白质圆二向色性的理论分析和实验研究。5.磁圆二向色性。

Measurements of optical activity have long played an essential role in the development of organic chemistry and biochemistry. The study of optical rotatory dispersion (ORD) or circular dichroism (CD) provides important information about the electronic states or structures of individual molecules or ions. These techniques are used when studying absolute configurations of molecules, reaction mechanisms and kinetics, asymmetric or stereospecific syntheses, thermodynamic properties of dissolved species, and many other stereochemical problems. This award from the Chemistry Research Instrumentation Program to the Department of Chemistry at the University of Colorado at Boulder will help them acquire a Circular Dichrograph. The acquisition will enhance chemical research in the following areas: 1. Circular Dichroism as a Method for Probing Ribozyme Conformation and Substrate Binding. 2. Applications of Circular Dichroism in Studies of Protein Structural Dynamics. 3. Solution Structures of Antimicrobial Peptides. 4. Analysis of Protein Circular Dichroism by Theory and Experiment. 5. Magnetic Circular Dichroism.