Kinetic Studies of Proton Transfer Reactions

通过这个续展奖项，有机和高分子化学项目支持科罗拉多大学博尔德分校的凯文·S·彼得斯博士的工作。这项研究旨在了解驱动力、溶剂、温度和氚同位素替代对溶液中质子转移动力学和机制的影响，使用事先获得资助的皮秒吸收光谱仪。本研究中使用的分子将包括2-(N-甲氨基)-α-苯乙酮和2-(苯胺甲基)-二苯甲酮的衍生物。这一发现将结合最近发展的两个理论进行检验，这两个理论认为质子转移只发生在受溶剂波动控制的隧道过程中。质子转移在许多有机和生化反应中发挥作用。彼得斯博士计划做的工作应该会为这类重要反应的详细机制提供有价值的见解。

With this renewal award the Organic and Macromolecular Chemistry Program supports the work of Dr. Kevin S. Peters at the University of Colorado at Boulder. The research aims to understand the influences of driving force, solvent, temperature, and deuterium isotope substitution on the kinetics and mechanism of proton transfer in solution, using a picosecond absorption spectrometer developed under a prior grant. The molecules used in this study will include derivatives of 2-(N-methyl-amino)-alpha-acetophenone and 2-(anilinomethyl)-benzophenone. The findings will be examined considering two recently developed theories which view proton transfer as occurring exclusively through a tunneling process controlled by solvent fluctuations.Proton transfer plays a role in many organic and biochemical reactions. The work that Dr. Peters proposes to do should provide valuable insights into the detailed mechanisms of this important class of reactions.