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Physiologically-based pharmacokinetic modelling of antibody-based drugs in children: Model development and population applications

Physiologically-based pharmacokinetic modelling of antibody-based drugs in children: Model development and population applications
儿童抗体药物的生理学药代动力学模型：模型开发和人群应用
批准号：
387255
负责人：
Malik Paul R
金额：
$7.65万
依托单位：
University of Waterloo (Ontario)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-10-01 至 2020-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=387255&lang=en
关键词：
Antibody-Drug Conjugates Biologics Drug Metabolism Monoclonal Antibodies Pediatrics Pharmacokinetics Pharmacology Pharmacy Physiologically-Based Pharmacokinetic Modelling Physiology

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Children need drug therapies for cancer and other serious diseases, just like adults. However, we cannot use the same drugs at the same doses to treat both adults and children. Children are not just little adults - simply giving a lower dose based on si
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