Tyrosine phosphorylation of caspase-8 regulates Toll Like Receptor 4 dependent signalling during clinical sepsis.

caspase-8 的酪氨酸磷酸化在临床脓毒症期间调节 Toll 样受体 4 依赖性信号传导。

• 批准号: 383329
• 负责人: Gupta Sahil
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-10-01 至 2020-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=383329&lang=en
• 关键词: Apoptosis; Caspase; Inflammation; Neutrophil; Sepsis; Toll-Like Receptor 4

During bacterial infection, white blood cells known as neutrophils mount a complex defense response to eliminate the infecting organisms. In healthy individuals, after the clearance of bacteria, neutrophils can terminate this response by undergoing a proc

在细菌感染期间，被称为中性粒细胞的白细胞会发起复杂的防御反应，以清除感染的微生物。在健康个体中，在清除细菌后，中性粒细胞可以通过经历一个过程来终止这种反应