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Inhibitors of PNT domain polymerization as a novel therapy to target ETV6 chimeric oncoproteins

Inhibitors of PNT domain polymerization as a novel therapy to target ETV6 chimeric oncoproteins
PNT 结构域聚合抑制剂作为靶向 ETV6 嵌合癌蛋白的新型疗法
批准号：
383323
负责人：
Gerak Chloe A
金额：
$7.65万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-10-01 至 2020-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=383323&lang=en
关键词：
Chemical Biology Fragment-Based Drug Design High-Throughput Screening Isothermal Titration Calorimetry Nuclear Magnetic Resonance Spectroscopy Oncoprotein Protein-Protein Interaction Receptor Tyrosine Kinase Structural Biology Transcription Facto

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I am studying cancers that result when the protein segment called PNT, encoded by the ETV6 gene, becomes improperly fused to another gene fragment that encodes a protein tyrosine kinase (PTK). This phenomenon is called a chromosomal translocation, and the
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