Pattern Formation in the Rat's Somatosensory System

DII和共聚焦显微镜的轨迹追踪方法将应用于哺乳动物新皮质的发育研究。胎鼠发育的正常顺序以及丘脑皮质传入和大脑半球间向新皮质的投射模式。此外，还将确定宫内摘除后肢对脑干和丘脑皮质投射神经元发育和皮质下后肢表征模式的影响。这些实验有望进一步阐明外周在大脑皮层发育过程中的作用。

Track tracing methods using DiI and confocal microscopy will be applied to study the development of mammalian neocortex. The normal sequence of development and the pattern of thalamocortical afferents and interhemispheric projections to the neocortex in the fetal rat. In addition, the effects of removing the hindlimb in utero on the development of cortical projection neurons and and subcortical hindlimb representation pattern in brainstem and thalamus will be determined. These experiments promise to further elucidate the role of the periphery in the development of cortical specification.