Pattern Formation in the Rat's Somatosensory System

大鼠体感系统的模式形成

• 批准号: 9022168
• 负责人: Herbert Killackey
• 金额: $ 22.49万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-15 至 1994-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9022168&HistoricalAwards=false
• 关键词: Pattern; Formation; Rat; Somatosensory; System

Track tracing methods using DiI and confocal microscopy will be applied to study the development of mammalian neocortex. The normal sequence of development and the pattern of thalamocortical afferents and interhemispheric projections to the neocortex in the fetal rat. In addition, the effects of removing the hindlimb in utero on the development of cortical projection neurons and and subcortical hindlimb representation pattern in brainstem and thalamus will be determined. These experiments promise to further elucidate the role of the periphery in the development of cortical specification.

使用DiI和共聚焦显微镜的轨迹跟踪方法将在 用于研究哺乳动物大脑皮层的发育。 的 正常的发育顺序和丘脑皮质的模式 传入和半球间的投射到新皮层， 胎鼠 此外，切除后肢的影响 对皮质投射神经元发育的影响， 和皮质下后肢代表模式， 丘脑将被确定。 这些实验承诺， 进一步阐明周边在发展中的作用， 皮质规格