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Homeostatic plasticity and the formation of neuronal assemblies in the rat hippocampus in vitro

体外大鼠海马的稳态可塑性和神经元组件的形成

基本信息

批准号：
163903388
负责人：
Professor Dr. Uwe Heinemann (†)
金额：
--
依托单位：
Instituto de Fisiología Celular
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2010
资助国家：
德国
起止时间：
2009-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/163903388?language=en
关键词：
Homeostatic plasticity formation neuronal assemblies

项目摘要

The consolidation of hippocampus-dependent memory is likely dependent on the replay of stored information during sharp wave-ripple complexes (SPW-Rs). We have recently shown that stimuli, which induce LTP in hippocampal area CA3, also induce SPW-Rs when such stimuli are repeatedly applied, and preliminary evidence suggests that SPW-Rs induced in area CA3 can induce LTP in area CA1. During stimulus-induced SPW-Rs a subset of neurons is active while many other neurons are inhibited. We suggest that formation of neuronal assemblies, which are active during SPW-Rs, requires adaptive changes in the neuronal network including heterosynaptic plasticity to limit output, to segregate different active ensembles from each other and to prevent epileptogenesis. Employing different stimulation protocols for the induction of SPW-Rs at different sites within both hippocampal slices and slice cultures, and using different intracellular und extracellular as well as multi-unit recording techniques, in part in combination with confocal Ca2+ imaging, we will study the role of heterosynaptic plasticity on the formation and stability of neuronal assemblies.

依赖于校园的记忆的巩固可能依赖于在尖波-波纹复合波（SPW-R）期间存储的信息的重放。我们最近的研究表明，在海马CA 3区诱导LTP的刺激，当重复施加这种刺激时，也会诱导SPW-Rs，初步证据表明，在CA 3区诱导的SPW-Rs可以诱导CA 1区的LTP。在刺激诱导的SPW-Rs的神经元的子集是活跃的，而许多其他神经元被抑制。我们认为，形成的神经元组件，这是活跃在SPW-Rs，需要适应性变化的神经元网络，包括异突触可塑性，以限制输出，隔离不同的活跃合奏彼此，以防止癫痫。采用不同的刺激方案，在不同的网站内海马切片和切片培养物的SPW-Rs的诱导，并使用不同的细胞内和细胞外以及多单位记录技术，部分结合共聚焦Ca 2+成像，我们将研究异突触可塑性的神经元组装体的形成和稳定性的作用。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reliable optical detection of coherent neuronal activity in fast oscillating networks in vitro

体外快速振荡网络中相干神经元活动的可靠光学检测

DOI：
10.1016/j.neuroimage.2011.12.018
发表时间：
2012
期刊：
NeuroImage
影响因子：
5.7
作者：
Reichinnek S;von Kameke A;Hagenston AM;Freitag E;Bading H;Hasan MT;Draguhn A;Both M
通讯作者：
Both M

Effects of the GABA‐uptake blocker NNC‐711 on spontaneous sharp wave–ripple complexes in mouse hippocampal slices

GABAα摄取阻滞剂NNCα711对小鼠海马切片自发锐波波纹复合物的影响