Maintenance and Distribution of Tfm Rats and Mice

睾丸雌性化突变（Tfm）发生在大鼠、小鼠、牛、黑猩猩和人类中。这种突变携带在X染色体上，所有携带这种突变的雄性都表现出对激素不敏感的表型。对Tfm突变的研究使我们对雄激素的作用模式，特别是雄激素与中枢神经系统蛋白之间的相互作用有了更深入的了解。GW小组维持着唯一已知的Tfm大鼠群体，并为研究界提供了宝贵的资源。

The testicular feminization mutation (Tfm) occurs in rats, mice, cattle, chimpanzee and humans. The mutation is carried on the X- chromosome and all males carrying this mutation exhibits the phenotype which is the insensitivity to the hormone, androgens. Studies of Tfm mutation have provided us with insights on the mode of action of androgens, particularly the interaction between the hormone and CNS proteins. The GW group maintains the only known colony of Tfm rats and serves as an invaluable resource for the research community.