Transition Metal Reagents in Organic Synthesis

施瓦茨博士的研究集中在两个领域。 第一、 过渡金属络合物将结合到氧化物载体上 这将成为它们的配体环境 为了防止配位不饱和物质的聚集， 稳定过渡金属的高氧化态，和 作为一种可变的配体， 可以调节刘易斯酸和羟基位点的量。 这些 复合物将探测动力学，结构和合成 问题研究 第二，早期过渡金属配合物将被 研究用作新的合成试剂。 将侧重 羟基酸催化转化为内酯 氧钨化合物的用途。 氧化物结合的制备 锆种类和与可溶性类似物的比较也将 执行。 %%% 有了这个奖项，化学合成有机计划 部门将支持杰弗里·施瓦茨博士的研究， 普林斯顿大学化学系。 的 研究是在综合方法的一般领域， 专注于有机过渡金属试剂领域 合成. 该项目的目标是找到金属 可以对有机物进行特定转化的络合物 在温和的条件下和高产率下使用底物。

Dr. Schwartz's research is focused on two areas. First, transition metal complexes will be bound to an oxide support which will then be a ligand environment for them by anchoring to prevent clustering of coordinatively unsaturated species, stabilizing high-oxidation states of the transition metal, and acting as a variable ligand in which basicity and availability of Lewis acid and hydroxylic sites can be adjusted. These complexes will be probed by kinetic, structural and synthetic studies. Second, early transition metal complexes will be studies for use as new synthetic reagents. The focus will be on the catalytic conversion of hydroxy acids into lactones by use of oxotungsten compounds. The preparation of oxide-bound zirconium species and comparisons to soluble analogs will also be carried out. %%% With this award, the Synthetic Organic Program of the Chemistry Division will support the research of Dr. Jeffry Schwartz of the Department of Chemistry at Princeton University. The research is in the general area of synthetic methodology and is focused on the areas of transition metal reagents in organic synthesis. The goals of the project are to find metal complexes which can perform specific transformations on organic substrates under mild conditions and in high yield.