Japan (JSPS) Postdoctoral Program: Role of N-Cadherin in Embryogenesis

该奖项将为哥伦比亚大学的Glenn Radice博士与日本京都大学的Masatoshi Takeichi博士开展合作研究提供补充支持。Radice博士将在日本武一博士的实验室工作一年，研究n -钙粘蛋白在胚胎发生中的作用。钙粘蛋白是细胞表面的蛋白，负责细胞间的粘附。胚胎发育过程中细胞分化成不同谱系的空间分离需要细胞间的选择性粘附。本研究将探讨胚胎发生过程中细胞选择性粘附的分子基础。Radice博士的背景是哺乳动物发育遗传学，takichi博士是细胞粘附领域公认的领导者。这项工作将为理解哺乳动物形态发生提供重要信息。

This award will provide supplementary support to enable Dr. Glenn Radice of Columbia University to conduct collaborative research with Dr. Masatoshi Takeichi of Kyoto University, Japan. Dr. Radice will spend one year working at Dr. Takeichi's lab in Japan, investigating the role of N-cadherin in embryogenesis. The cadherins are cell- surface proteins responsible for cell-cell adhesions. Spatial segregation of cells differentiating into distinct lineages during embryonic development requires selective intercellular adhesions. This study will investigate the molecular basis for selective cell adhesion during embryogenesis. Dr. Radice's background is in mammalian developmental genetics and Dr. Takeichi is a recognized leader in the field of cellular adhesion. This work should provide critical information for the understanding of mammalian morphogenesis.