Japan (JSPS) Postdoctoral Program: Role of N-Cadherin in Embryogenesis

该奖项将提供补充支持，使格伦博士 哥伦比亚大学的Radice与 日本京都大学的竹一正敏博士。 拉迪斯医生会 在日本武市博士的实验室工作了一年， N-钙粘蛋白在胚胎发生中的作用。 钙粘蛋白是细胞- 负责细胞-细胞粘附的表面蛋白。 空间 分离细胞分化成不同的谱系， 胚胎发育需要选择性的细胞间粘附。 本研究将探讨选择性细胞的分子基础 胚胎发生过程中的粘附。 拉迪斯博士的背景是在哺乳动物发育遗传学和博士。 Takeichi是细胞粘附领域公认的领导者。 这项工作应提供关键信息， 哺乳动物的形态发生

This award will provide supplementary support to enable Dr. Glenn Radice of Columbia University to conduct collaborative research with Dr. Masatoshi Takeichi of Kyoto University, Japan. Dr. Radice will spend one year working at Dr. Takeichi's lab in Japan, investigating the role of N-cadherin in embryogenesis. The cadherins are cell- surface proteins responsible for cell-cell adhesions. Spatial segregation of cells differentiating into distinct lineages during embryonic development requires selective intercellular adhesions. This study will investigate the molecular basis for selective cell adhesion during embryogenesis. Dr. Radice's background is in mammalian developmental genetics and Dr. Takeichi is a recognized leader in the field of cellular adhesion. This work should provide critical information for the understanding of mammalian morphogenesis.