Structural and molecular studies of endocrine disruption in Australia fauna

澳大利亚动物群内分泌干扰的结构和分子研究

• 批准号: DP230100609
• 负责人: A/Prof John Bruning
• 金额: $ 40.26万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100609
• 关键词: Structural; molecular; studies; endocrine; disruption

Contamination of waterways with compounds that disrupt hormone (endocrine) function is a major environmental problem and threat to the health and fertility of animals. Specifically, we lack an understanding of how these potent endocrine disrupting compounds function in native species. Using an innovative combination of structural and molecular biology approaches we will elucidate the mechanisms of action of environmental endocrine disrupting compounds in native aquatic species - model fish and the platypus; and develop novel technologies for their detection. This work will provide an understanding of the environmental threat of these pollutants to our unique wildlife and will guide future waterway management.

水道被扰乱激素(内分泌)功能的化合物污染是一个主要的环境问题，对动物的健康和生育能力构成威胁。具体地说，我们缺乏对这些强大的内分泌干扰化合物如何在本土物种中发挥作用的了解。我们将采用创新的结构和分子生物学相结合的方法，阐明环境内分泌干扰物在本地水生物种--模式鱼和鸭嘴兽中的作用机制；并开发新的检测技术。这项工作将有助于了解这些污染物对我们独特的野生动物的环境威胁，并将指导未来的航道管理。