Neuroprotective Effect of Sigma-1 Receptor and Activin A on Synaptic Function and Calcium Handling in Huntington's Disease

Sigma-1 受体和激活素 A 对亨廷顿病突触功能和钙处理的神经保护作用

• 批准号: 396708
• 负责人: Nassrallah Wissam B
• 金额: $ 10.93万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=396708&lang=en
• 关键词: Behaviour Studies; Calcium Homeostasis; Calcium Imaging; Confocal Imaging; Electrophysiology; Endoplasmic Reticulum; Fiber Photometry; Huntington'S Disease; Microscopy; Synaptic Function

Huntington's disease (HD) is a devastating inherited disease that can be detected before symptoms arise, but which is incurable. In HD patients, neurons involved in motor functions deteriorate, causing motor and cognitive problems. Neurons transmit signal

亨廷顿舞蹈病（HD）是一种毁灭性的遗传性疾病，可以在症状出现之前检测到，但无法治愈。在HD患者中，参与运动功能的神经元恶化，导致运动和认知问题。神经元传递信号