Base Stable and Composite ZrO2 Ceramic Supports for HPLC

该合作奖是在材料化学和化学处理计划下制定的，由化学和化学及热系统部门提供支持。该研究的目标是开发一系列技术先进的单分散、宽孔、高内表面积、机械和ph稳定的多孔氧化锆颗粒，用于分离科学。新型陶瓷材料将符合当前和未来生化材料下游加工的需要。根据材料所需的几何、机械和化学特性，颗粒将被优化以完成各种各样的分离任务。优化将包括颗粒表面的化学修饰和高低温处理步骤。在合成和表面处理之后，颗粒将在各种最终用途中进行表征和评估。这将是一个迭代的过程。这项研究将开发一个基于氧化锆多孔微球的多面支撑家族，用于分析和制备级色谱以及流化床分离。该研究的目的是通过用氧化锆代替二氧化硅来克服与硅基支撑相关的主要问题，并利用这种衬底的独特分离化学。

This collaborative award, made under the Materials Chemistry and Chemical Processing Initiative is supported by the Divisions of Chemistry and Chemical and Thermal Systems. The goal of the research is the development of a family of technically advanced monodisperse, wide-pore, high internal surface area, mechanically and pH-stable, porous zirconia particles for use in separations science. Novel ceramic materials will be made that conform to the needs of the current and future downstream processing of biochemical materials. Based on the required geometric, mechanical and chemical characteristics of the materials, the particles will be optimized to accomplish a wide variety of separation tasks. Optimization will include chemical modification of particle surfaces and high and low temperature processing steps. Following synthesis and surface treatment, particles will be characterized and evaluated in a variety of end uses. This will be an iterative process. %%% This research will develop a multi-faceted family of supports based on porous microspheres of zirconia to be used in both analytical and preparative-scale chromatography and in fluidized bed separations. The objective of the research is to overcome the major problems associated with silica-based supports by replacing silica with zirconia and to exploit the unique separations chemistry of this substrate.