Structure, Energetics and Reaction Dynamics of Bimolecules in the Gas Phase

气相双分子的结构、能量和反应动力学

• 批准号: 9108318
• 负责人: Jesse Beauchamp
• 金额: $ 48.58万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1994-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9108318&HistoricalAwards=false
• 关键词: Structure; Energetics; Reaction; Dynamics; Bimolecules

Professor Beauchamp is supported by a grant from the Experimental Physical Chemistry Program to investigate the properties, structures, and reaction dynamics of biomolecules in the gas phase. The long term objective is to devise rapid and reliable methods for amino acid and nucleotide sequence determinations with subpicomole samples. Soft ionization techniques, including laser desorption, fast atom bombardment, and electrospray ionization will be used to form singly and multiply charged molecular ions of thermally fragile biomolecules. The major technique for characterization is Fourier transform ion cyclotron resonance spectroscopy. %%% The determination of the sequence of amino acids in proteins and of the base pairs in nucleotides requiring only minute samples will be carried out using techniques which gently remove electrons from these thermally fragile biomolecules, and then trap, manipulate and detect the ions which have been formed.

比彻姆教授得到了 实验物理化学计划，以调查 生物分子的性质、结构和反应动力学 在气相中。 长期目标是设计快速 氨基酸和核苷酸序列的可靠方法 使用亚皮摩尔样品进行测定。 软电离 技术，包括激光解吸，快速原子轰击， 和电喷雾电离将用于单独形成， 多电荷热脆性分子离子 生物分子 表征的主要技术是 傅里叶变换离子回旋共振光谱学。 %%% 蛋白质中氨基酸序列的测定 而核苷酸中的碱基对只需要几分钟 将使用温和的技术进行采样， 从这些热脆弱的生物分子中移除电子， 然后捕获，操纵和检测已经被 形成了