Alkoxycyclopropyl and Cyclobutylphosphonium Salts: Preparation and Reaction in a Tandem Ring Expansion Wittig Reaction

该项目涉及形成含有烷氧基和芳基磷盐官能团的应变环，以便评估它们在串联环扩张- wittig反应中的效用。由-氧磷盐衍生物制备烷氧基环丙基和环丁基磷盐。这些取代应变环的形成尚未见报道，因此一种有效的合成方法具有明确的价值。此外，它们的制备将为β -氧磷盐的反应性和应用提供新的见解，β -氧磷盐本身就是重要的威廷反应前体。最后，对这些应变环的环解理以及随后的Witting反应的研究将确定该方法是否适用于更复杂体系的开发。研究计划补助金使以前没有获得独立的联邦研究支持的妇女能够制定具有竞争力的研究计划。该项目涉及有机化学反应，产生大量天然产物中常见的中型环。

This project involves the formation of strained rings containing both alkoxy and arylphosphonium salt functional groups so that their utility in a tandem ring expansion-Wittig reaction can be assessed. The alkoxycyclopropyl and cyclobutyl phosphonium salts will be prepared from beta-oxophosphonium salt derivatives. Formation of these substituted strained rings has not been reported, so an efficient method leading to their synthesis is of clear value. In addition, their preparation will lend new insights into the reactivity and applications of the beta-oxophosphonium salts, which are themselves important Witting reaction precursors. Finally, the study of the ring cleavage of these strained rings followed by a subsequent Witting reaction will determine whether this method will be suitable for development in more complex systems. %%% Research Planning Grants enable women who have not had prior independent Federal research support to develop a competitive research proposal. This project involves organic chemical reactions leading to medium-sized rings which are common in a large number of natural products.