Understanding the mechanisms that inhibit and promote biofilm expansion

了解抑制和促进生物膜扩张的机制

• 批准号: DP230100406
• 负责人: A/Prof Benjamin Binder
• 金额: $ 31.38万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100406
• 关键词: Understanding; mechanisms; inhibit; promote; biofilm

Yeasts have been used for biotechnology throughout recorded history. They are important human pathogens, and major experimental models of eukaryotic cells. Although yeasts are some of the most studied organisms in biology, their modes of colony biofilm formation are not fully understood. Methods to investigate the environmental and genetic processes that drive colony biofilm formation will be developed in this proposed project. They will provide a deeper understanding of the mechanisms that inhibit and promote biofilm formation, and colonial morphology in the different modes of growth of Saccharomyces cerevisiae, with implications for this and other biofilm-forming yeasts of biotechnological or medical importance.

在有记录的历史中，酵母菌一直被用于生物技术。它们是人类重要的病原体，也是真核细胞的主要实验模型。虽然酵母菌是生物学中研究最多的生物之一，但它们的菌落生物膜形成模式尚不完全清楚。在这个拟议的项目中，将开发研究驱动菌落生物膜形成的环境和遗传过程的方法。它们将提供对抑制和促进生物膜形成的机制以及酿酒酵母在不同生长模式下的菌落形态的更深层次的理解，对这一生物膜形成酵母和其他具有生物技术或医学意义的生物膜形成酵母具有重要意义。