Quantifying yeast cell mechanisms: filamentous growth and biofilm formation

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This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of tissues. The project plans to develop methods to quantify the mechanisms driving these growth processes. These methods will be designed to permit classification and selection of strain-specific properties of yeasts, providing a deeper understanding of the mechanisms controlling cellular and colonial morphology in the growth of Saccharomyces cerevisiae, the most important yeast in both biotechnology and bioscience.