Quantifying yeast cell mechanisms: filamentous growth and biofilm formation

量化酵母细胞机制：丝状生长和生物膜形成

• 批准号: DP160102644
• 负责人: A/Prof Benjamin Binder
• 金额: $ 24.96万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-23 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102644
• 关键词: Quantifying; yeast; cell; mechanisms; filamentous

This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of tissues. The project plans to develop methods to quantify the mechanisms driving these growth processes. These methods will be designed to permit classification and selection of strain-specific properties of yeasts, providing a deeper understanding of the mechanisms controlling cellular and colonial morphology in the growth of Saccharomyces cerevisiae, the most important yeast in both biotechnology and bioscience.

该项目旨在量化酵母生长的细胞机制，以促进我们对这些生物的理解，并支持预防和治疗疾病的策略。虽然酵母是生物学中研究最多的生物之一，但其丝状生长和生物膜形成的模式尚不完全清楚。酵母菌如念珠菌通过丝状侵入组织引起潜在的致命感染。该项目计划开发方法来量化驱动这些增长过程的机制。这些方法将被设计用于对酵母的菌株特异性特性进行分类和选择，从而更深入地了解酿酒酵母（Saccharomyces cerevisiae）生长过程中控制细胞和群体形态的机制。酿酒酵母是生物技术和生物科学中最重要的酵母。